--RESEARCH--

Learning and Memory

NSCs and Recognition Functions

The hippocampal neurogenesis decreases with aging, which is believed to be associated with declines in recognitive functions. Our research interest is on the mechanisms of neural stem cell exhaustion during aging.

TIA and Recognition Dysfunction

Hippocampal dependent cognitive dysfunction occurs after TIA. In order to find appropriate treatment strategies, we want to explore what is the mechanism of brain injury after TIA?

Engram cell and Memory Precision

Hippocampal dentate engram cells play an important role in memory rerieval,but their downstream connectivity are still unclear.Thus we focus on "how do engram cells and neural circuits in hippocampal CA3 regulate memory precision"?

Adolescent Stress and Recognition

Adolescent stress can lead to a range of changes in adulthood,we want to know,after social isolation in adolescent,"how much you see I'm like before?" and the mechanisms about it.






--Publications--

Click for journal website

 Guo N，Sahay A et al. (2022) Transcriptional regulation of neural stem cell expansion in the adult hippocampus. Elife. 2022.


 Vicidomini C, Guo N, Sahay A. (2020) Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche. Neuron. 2020.


 Guo N，Sahay A et al. (2018) Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med. 2018.


 Guo N，Sahay A. (2017) Neural Circuits Serve as Periscopes for NSCs. Cell Stem Cell. 2017.


 McAvoy KM, Scobie KN, Berger S, Russo C, Guo N,Sahay A et al. (2016) Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits.   Neuron. 2016.

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